Lefats'eng la meriana le la phepo e nepahetseng, Noopept e fumana tlhokomelo e le ntho e ka ntlafatsang ts'ebetso ea kelello le neuroprotectant. Aogubio ke k'hamphani e ka sehloohong e sebetsanang le tlhahiso le thekiso ea lintho tse sebetsang ka meriana, lisebelisoa tse tala le lihlahisoa tsa limela, ho akarelletsa le Noopept. Setlhare sa maiketsetso se entsoeng ke k'hamphani ea Russia, Noopept hangata e bitsoa nootropic ka lebaka la bokhoni ba eona ba ho ntlafatsa tsebo. Ho blog ena, re tla hlahloba melemo le ts'ebeliso ea Noopept, hammoho le tšusumetso e ka bang teng ho ts'ebetso ea kelello le bophelo bo botle ka kakaretso.
Noopept ke eng?
Noopept, eo hape e tsejoang e le N-phenylacetyl-L-prolylglycine ethyl ester, ke motsoako o ntseng o ithutoa bakeng sa bokhoni ba oona ba ho ntlafatsa ts'ebetso ea kelello le ho loantša matšoenyeho. Sebopeho sa Noopept se thehiloe ho Piracetam, e 'ngoe e tsebahalang ea nootropic, e bontšitsoeng hore e na le lisebelisoa tsa neuroprotective mme e ka ba le liphello tse ntle mohopolong le thutong. Aogubio e ka pele ho ho fana ka Noopept ea boleng bo holimo bakeng sa tšebeliso ea tlatsetso, meriana le liindasteri tse ling.
Joang Noopept Works
Noopept ke sethethefatsi se tsebahalang se ntlafatsang kelello se sebetsang ka ho potlakisa mokhoa oa ho theha mohopolo le ho khutlisa. E etsa sena ka ho matlafatsa maemo a "brain-derived neurotrophic factor" (BDNF), motsoako o khothalletsang kholo ea lisele tsa boko. Hape, Noopept e etsa hore li-receptor tsa acetylcholine (ACh) bokong li arabele haholoanyane ho neurotransmitter (kelello ea lik'hemik'hale) ea acetylcholine, e leng eona e lumellang hore ho be le melaetsa e potlakileng le e sebetsang haholoanyane pakeng tsa methapo ea kutlo.
Melemo ea Noopept
E Ntlafatsa Mosebetsi oa Kelello
Bopaki bo bongata ba kliniki bo tšehetsa melemo ea Noopept libakeng tse fapaneng tsa ts'ebetso ea kelello joalo ka mohopolo, ho ithuta le bokhoni ba ho nahana:
- Ho bakuli ba nang le tšitiso ea kelello e bakoang ke ho tsieleha kapa maloetse a boko ba methapo ea mali, Noopept e ntlafalitse mosebetsi oa boko joalokaha ho pakoa ke matla a eketsehileng a alpha-le beta-rhythms ho electroencephalogram (EEG).
- Tsamaiso ea Noopept ka tekanyo ea 20 mg letsatsi le leng le le leng bakeng sa likhoeli tsa 2 e ntlafalitse ts'ebetso ea kelello ho bakuli ba nang le stroke 'me ba na le boemo bo phahameng ba tšireletso.
- Mefuteng e mengata ea liphoofolo tsa lefu la Alzheimer (AD), Noopept e sirelelitse lisele tsa boko ba rat khahlanong le chefo ea amyloid beta (moemeli oa causative oa AD) ka ho thibela tšenyo ea oxidative, ho thibela khalsiamo e ngata, le ho hatella apoptosis (programed cell death).
- Tsamaiso e pheta-phetoang ea Noopept ho likhoto e ntlafalitse thuto ha e bapisoa le tekanyo e le 'ngoe.
- Ka mohlala oa rat oa stroke, Noopept o bontšitse ka bobeli thepa ea ho tsosolosa tsebo le neuroprotective.
- Boemong bo tloaelehileng le ba Down's syndrome bokong ba motho, Noopept e ile ea thibela tšenyo ea oxidative le apoptosis.
- Likhotong tse hlokomelang, tsamaiso ea Noopept e ile ea eketsa ts'ebetso ea boko ho EEG.
- Noopept e na le bokhoni ba ho eketsa maemo a Nerve Growth Factor le Brain Derived Neurotrophic Factor, e amanang le ntlafatso e sa foleng ea mohopolo.
- Noopept e ka thusa ho ntlafatsa ts'ebetso ea kelello ka ho ntlafatsa matšoao a motlakase lipakeng tsa methapo ea kutlo.
- Noopept ka karo-karolelano ea 1: 1 kapa makhetlo a leshome ho feta ho ile ha bonahala ho fokotsa haholo maemo a 'mele ea Lewy (li-protein clumps tse bakang lefu la Parkinson) bokong.
- Ho litoeba tse nang le bothata ba ho ferekana, tsamaiso e sa foleng ea Noopept e ile ea eketsa katleho ea anticonvulsant drug valproate.
- Phuputso e tlalehile hore Noopept e sebelisa liphello tsa eona tsa neuroprotective ka thepa ea eona ea antioxidant le e khahlanong le ho ruruha.
- Ka likhoto, Noopept e ntlafalitse phetiso ea matšoao a methapo bokong.
- Ho litoeba, Noopept e ile ea thibela ka ho feletseng tsoelo-pele ea mathata a kelello a bakoang ke scopolamine.
- Likhotong, Noopept e ile ea fetola ho senyeha ha kelello ka ho eketsa maemo a boko bo tsoang bokong ba neurotrophic factor (BDNF).
- Moetsong oa toeba oa lefu la Alzheimer, Noopept e thibetse ho senyeha ha mohopolo.
- Liphuputso li tlalehile hore Noopept e ka thusa ho thibela lefu la Alzheimer ka ho thibela ho thehoa ha liprotheine tse sa tloaelehang bokong le ho fokotseha ha mosebetsi oa khatello ea kelello-activated mitogen-activated protein kinases (MAPK).
- Ho litoeba, ente ea Noopept metsotso ea 5 pele ho ithuta e ntlafalitse mohopolo oa nako e telele.
- Ho likhoto tse nang le stroke, phekolo ea Noopept e ile ea fokotsa sebaka sa infarction (lithane tse shoeleng) bokong.
- Likhotong, tsamaiso ea Noopept ho 5 mg / kg ka liente e hlahisitse liphello tse matlafatsang tsebo.
- Tsamaiso ea 0.5-10 mg / kg ea Noopept ka likhoto e ile ea susumetsa thuto ea thuto e le 'ngoe ka mor'a tsamaiso e le' ngoe, ha tsamaiso e pheta-phetoang e eketsa bokhoni ba ho ithuta ba likhoto tse ileng tsa hlōleha koetliso ea pele mosebetsing oa ho qoba ho qoba (teko e hlahlobang ho ithuta le mohopolo) .
- Tsamaiso ea Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) ka tekanyo ea 0.5 mg / kg metsotso ea 15 pele ho qala maze ea Morris e entse hore ho be le ntlafatso e kholo mohopolong oa nako e telele.
- Likhotong tse nang le khatello ea kelello e bakoang ke cerebral ischemia, tsamaiso ea Noopept ka liente le tsela ea molomo e ntlafalitse ho fumana likarabo tsa ho qoba ho qoba.
- Phuputso ea lisele e fumane hore Noopept e thibela neurodegeneration e bakoang ke glutamate le khatello ea oxidative.
- Likhotong tse neng li e-na le bokooa ba kelello ka lebaka la lobectomy, mokhoa o kenyelletsang ho tlosoa ha lobe eohle ea boko, Noopept e ile ea khothalletsa tsosoloso ea thuto le mohopolo.
- Phuputso ea lisele e tlaleha hore Noopept e ntlafalitse phetiso ea lipontšo pakeng tsa lisele tsa boko.
E Loana le Matšoenyeho
- Bokhoni ba ho ntlafatsa kelello ba Noopept bo boetse bo hlahisa phello e khahlanong le ho tšoenyeha ho latela lithuto:
- Tsamaiso ea Noopept ho bakuli ba nang le bokooa bo fokolang ba kelello e fokolitse mokhathala, matšoenyeho le ho teneha.
- Ho bakuli ba nang le lefuba le sa tsoa fumanoa la ho hema, phekolo ea Noopept e fokolitse lipontšo tsa ho tšoenyeha.
- Likhotong, tsamaiso ea Noopept e ne e amahanngoa le ho eketseha ha mosebetsi oa locomotor tekong e phahameng ea maze, e fana ka maikutlo a phello e khahlanong le ho tšoenyeha.
- Tsamaiso ea Noopept e boetse e ekelitse boitšoaro ba ho hlahloba likhoto tse etsoang tekong e bulehileng, e leng sesupo sa ho fokotsa matšoenyeho.
- Ka litoeba, tsamaiso ea Noopept hlahisa modulation ea boemo ba ho tšoenyeha.
- Ho likhoto, Noopept e fokolitse liketsahalo tsa ho hloka thuso ho ithuta.
- Ho litoeba tse tsoang mefuteng e fapaneng, Noopept e fokolitse maemo a khatello ea maikutlo joalokaha ho pakoa ke palo e eketsehileng ea liketso tsa ho qoba tekong ea khatello ea kelello e bakang khatello ea maikutlo.
- Likhotong tse nang le matsatsi a 4, Noopept e ile ea fetola matšoao a khatello ea kelello e bakoang ke hormone ea corticotropin e lokollang (CRH).
- Ka mefuta e sa tšoaneng ea litoeba, tsamaiso ea Noopept ka 1 mg ka kg letsatsi le leng le le leng e hlahisitse liphello tse khahlanong le ho tšoenyeha ka letsatsi la 7th.
E ntlafatsa Boikutlo
Noopept e ka boela ea thusa ho ntlafatsa maikutlo, ho etsa hore e be khetho ea phekolo bakeng sa mathata a itseng a bophelo bo botle ba kelello:
- Tsamaiso ea nako e telele ea Noopept (matsatsi a 21) e ile ea felisa haholo lipontšo tsa ho hloka thuso ho ithutoang ha li bapisoa le lithethefatsi tse khahlanong le ho tšoenyeha Afobazol.
- Tsamaiso ea nako e telele (matsatsi a 28, 0.5 mg / letsatsi ka liente) ea Noopept e ntlafetseng ea boitšoaro ka ho fokotsa mosebetsi oa kinase e bakoang ke khatello ea kelello (e amanang le mathata a kelello) le ho eketsa maemo a BDNF.
Ka kakaretso, Noopept ke motsoako o tšepisang o nang le melemo e ka bang teng bakeng sa ts'ebetso ea kelello, matšoenyeho le maikutlo. Aogubio ke mohloli o ka tšeptjoang oa boleng bo phahameng ba Noopept le lintho tse ling tse sebetsang ka meriana, ho netefatsa hore bareki ba fumana litharollo tse ka tšeptjoang, tse sebetsang bakeng sa litlhoko tsa bona tsa bophelo bo botle le bophelo bo botle. Ebang e sebelisoa ho li-supplement, meriana, kapa lisebelisoa tse ling, Noopept e na le monyetla oa ho etsa phapang e utloahalang bophelong ba basebelisi. Ha tlhoko ea lintlafatso tsa tlhaho ea kelello e ntse e hola, AoguBio e ntse e ikemiselitse ho fana ka lihlahisoa tse ncha ho fihlela litlhoko tse lulang li fetoha tsa bareki ba rona.
Ho ngola sengoloa: Miranda Zhang
Nako ea poso: Mar-11-2024
