Deoxyarbutin, e le tlhōlisano ea Tyrosinase inhibitor, e ka laola tlhahiso ea melanin, ea hlōla mebala ea mebala, e senya matheba a matšo a letlalo, 'me e na le phello e potlakileng le e tšoarellang ea ho soeufala ha letlalo. Tšusumetso e thibelang ea deoxyaarbutin ho Tyrosinase ho hlakile hore e phahametse li-activator tse ling tse soeufalang, 'me phello e tšoeu le e khanyang e ka finyelloa ka tšebeliso e fokolang. Deoxyarbutin e boetse e na le litlamorao tse matla tsa antioxidant
- Lebitso la Sechaena Deoxyarbutin
- Lebitso la kantle ho naha Deoxyarbutin
- Lebitso la bosoasoi p - (tetrahydro-2H-pyran-2-oxy) phenol
- Foromo ea lik'hemik'hale C11H14O3
- Boima ba molek'hule 194.23
- Nomoro ea ho kena ea CAS 53936-56-4
- Senyesemane alias 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Bohloeki ≥ 98%
Deoxyarbutine le moloko o mocha oa litlolo tse khanyang le tse soeufatsang tse sebetsang, li sebelisoa haholo-holo ho litlolo tse tsoetseng pele tse soeufatsang.
Teko
Ho feto-fetoha ha melanogenesis ka har'a melanocyte ho ka finyelloa ho sebelisoa lik'hemik'hale tse arolelanang li-homologies tsa sebopeho le substrate tyrosine 'me ka hona li thibela tšebetso ea catalytic ea tyrosinase ka tlholisano. Re thehile tyrosinase inhibitor e ncha, deoxyArbutin (dA), e thehiloeng motheong ona. DeoxyArbutin e bonts'a thibelo e sebetsang ea mushroom tyrosinase in vitro ka Ki e tlase ka makhetlo a 10 ho feta hydroquinone (HQ) le ka makhetlo a 350 ho feta arbutin. Moetsong oa khaka e se nang moriri, e mebala-bala, dA e bonts'itse ho benya ha letlalo ka potlako le ka nako e telele ho ileng ha khutlisoa ka botlalo nakong ea libeke tse 8 ka mor'a ho emisa ts'ebeliso ea lihlooho.
Ka lehlakoreng le leng, HQ e hlahisitse phello e khuts'oane empa e sa tsitsang ea letlalo athe kojic acid le arbutin ha li na phello e khanyang ea letlalo. Liphetho tse tsoang sehlopheng sa liteko tsa polokeho li tšehetse ho thehoa ha dA ka kakaretso e le molek'hule e ka sebetsang. Tekong ea kliniki ea batho, phekolo ea lihlooho tsa dA bakeng sa libeke tse 12 e ile ea fella ka phokotso e kholo kapa e fokolang ea khanya ea letlalo ka kakaretso le ntlafatso ea lentigine ea letsatsi ho baahi ba letlalo le khanyang kapa batho ba letlalo le lefifi, ka ho latellana. Lintlha tsena li bonts'a hore dA e na le ts'ebetso e ka thibelang tyrosinase e ka etsang hore letlalo le khanye 'me e ka sebelisoa ho ntlafatsa liso tsa hyperpigmentary.
Selelekela
Melasma (chloasma) ke lefu le tloaelehileng la 'mala oa letlalo le khetholloang ke khanya e sa tsitsang ho ea ho litoeba tse sootho sefahlehong, tse atisang ho baka moroalo o moholo oa kelello le kelello ho batho ba amehileng. Leha ho le joalo, liketsahalo tse susumetsang bakeng sa pathogenesis ea melasma ha li utloisisoe hantle. Melasma e atile haholo ho batho ba nang le mefuta ea letlalo la Fitzpatrick IV ho isa ho VI ho feta ho ba nang le letlalo le letle (mofuta oa I ho isa ho oa III). Melasma e boetse e tsejoa e le e atileng haholo har'a basali ho feta banna mme e atile haholo har'a Maasia, Latinos le Maafrika-Amerika ho feta har'a batho ba Caucasus. Ho hakanngoa hore 50% ho isa ho 70% ea basali ba bakhachane United States ba ba le melasma [3].
Ho fumanoe hore melanocyte ea hyperactive letlalong la melasma e hlahisa melanin pigment e ngata ka tsela ea tyrosine catabolism. Tyrosinase (EC 1.14.18.1), glycoprotein e nang le koporo, ke enzyme e fokotsang sekhahla e bohlokoa tseleng ena. Melanin synthesis e etsahala ka har'a li-organelles tse ikhethang tse bitsoang melanosomes ebe melanosomes ea melanosome e fetisoa ho tloha ho melanocyte ho ea ho keratinocyte ea boahelani, ka hona ho khetholla 'mala oa letlalo o nang le matla le a matla. Lisebelisoa tse ngata tse khantšang letlalo li shebane le ho laola motsoako oa melanin ka ho thibela ts'ebetso ea tyrosinase. Lilemong tse 50 tse fetileng, hydroquinone (1, 4-benzenediol, HQ) esale e sebelisoa haholo joalo ka tekanyetso ea khauta ea prototypical tyrosinase inhibitors ho alafa melasma. Leha ho le joalo, ho se ho lebisitsoe tlhokomelo ea morao-rao ho kotsi e ka 'nang ea e-ba teng ea bophelo bo botle ba nako e telele ea ho pepesehela HQ, joalo ka exogenous ochronosis, leukoderma (occupational vitiligo), esita le carcinogenesis. mosebetsi, ho fana ka monyetla oa ho soeufala ha letlalo. Ho sa le joalo, metsoako ena ea monophenol e boetse e fana ka tlhahiso, ka enzymatic oxidation ka tyrosinase, ho li-radicals tse ngata tsa mahala tse bakang lipid peroxidation le tšenyo e bakoang ke melanosomal membrane. -pyran-2-yl) oxy] phenol, D-Arb), glucoside e nkiloeng ho HQ, e bolokehile ebile ha e na cytotoxic ha e bapisoa le motsoako oa 'm'a eona oa hydroquinone. Boithuto ba hajoale bo entsoe ho batlisisa chefo le katleho ea D-Arb maemong a sub-cellular (ka kotloloho ho melanosomes) le mebala ea letlalo e sebelisang mefuta ea vivo le in vitro, ho lekola ho feta ha biosafety ea D-Arb papisong le HQ. bakeng sa tshebediso ya ho kgantsha letlalo.
Deoxyarbutin, e le moloko o mocha oa litlolo tse khanyang le tse soeufatsang tse sebetsang, li sebelisoa haholo-holo ho litlolo tse tsoetseng pele tse soeufatsang.
D-Arbutin ke e 'ngoe ea lintho tse tsoang ho Arbutin, e bitsoang D-nenenebb arbutin, e ka thibelang hantle ts'ebetso ea tyrosinase liseleng tsa letlalo. Ho latela lipatlisiso, phello ea eona e bile makhetlo a 10 ho feta ea hydroquinone le makhetlo a 350 a Arbutin ka kakaretso. Litekong tsa letlalo la liphoofolo, D-Arbutin ena e ka soeufatsa letlalo kapele le ka nepo, mme kamora ho khaotsa ho sebelisa, phello e ntse e ka bolokoa hoo e ka bang libeke tse 8.
Lithutong tsa bongaka tsa 'mele oa motho, tšebeliso ea mantlha ea D-Arbutin bakeng sa libeke tse 12 e ka fihlela litlamorao tse kholo tsa ho bentša letlalo,' me e na le phello e ntle ea ntlafatso libakeng tse pepesehang khanya ea letsatsi le letsatsi le maemo a letlalo le lefifi.
Nako ea poso: Jul-11-2023
