Nattokinase ke eng?
Nattokinase (NK) ke Bacillus subtilis protein kinase, serine protease e hlahisoang ke Bacillus subtilis natto nakong ea ho belisoa ha natto. E na le mesebetsi ea ho qhibiliha mali, ho fokotsa viscosity ea mali, ho ntlafatsa phallo ea mali, ho nolofatsa le ho eketsa elasticity ea vascular.
Ka 1980, ho ile ha fumanoa Natto hore e na le li-amino acid tse 275 tse hlophisitsoeng ka mokhoa o tsitsitseng, ka boima ba molek'hule 27724. E na le mosebetsi o ikhethang oa ho senya mali, 'me phello ea eona e sebetsang e emeloa ke yuniti ea intrinsic FU.
Lintho tsa 'mele le tsa lik'hemik'hale
Nattokinase e potlakile ho etsa denature le ho tima mocheso o fetang 80 ℃, empa ho qhibiliha khafetsa ha leqhoa ho na le phello e fokolang ho eona.
Nattokinase e tsitsisa ka hare ho metsotso e 10 ha pH ea boleng e eketseha ho tloha ho 7 ho ea ho 12; Ha pH ea boleng e le ka tlase ho 5, e fetoha ka potlako 'me e se e sa sebetse.
Kamora ho kopanya nattokinase le lintho tsa viscous, e ka boloka ts'ebetso e sa feteng 7.5% tikolohong e nang le asiti e nang le pH ea 2-3.
Nattokinase ke molek'hule e kholo ea peptidase ea ketane e le 'ngoe e ka aroloang ka likhechana tsa amino acid kapa liketane tse nyane tsa boima ba molek'hule ka lero la mala (chymotrypsin, trypsin, mokelikeli oa mala a manyane, joalo-joalo).
Boleng ba phepo ea natto
Natto ke lijo tse sebetsang hantle tse entsoeng ka linaoa tsa soya tse phehiloeng tse lomositsoeng ke baktheria. Ntle le ho boloka limatlafatsi tsa soya e tala, e boetse e na le likarolo tse itseng tse kang protheine, fiber, calcium, iron, potasiamo le divithamini ho feta linaoa tsa soya tse phehiloeng.
Liteng tsa biotin B1, vithamine B2, le liminerale tse ling, haholo-holo k'halsiamo, tšepe le potasiamo, li feta tsa mahe. Haeba ho bapisa natto le mahe le nama ea khomo, protheine ea 100g ea natto e lekana le mahe a 3 kapa 80g ea nama ea khomo. Amino acid content ka natto e boetse e ruile haholo, e leng ka lebaka la tlhahiso ea livithamine tse sa tšoaneng le li-enzyme nakong ea ho belisoa, tse kang amylase, protease, lipase, cellulase, nattokinase, lysozyme, glutamic acid transpeptidase, joalo-joalo. ketso ea li-enzyme, liprotheine le limatlafatsi tse ling lia senyeha, kahoo sekhahla sa ho sila ha natto (85%) se phahame ho feta sa soya e phehiloeng (68%), e nang le phepo e nepahetseng le ho monya habonolo.
Patlisiso ea karolo
NattoKinase (NK) ke protheine e boima ba molek'hule e nyane haholo ho feta UK, SK, le tPA, e ntšitsoeng ho natto ea lijo kapa e lomositsoeng ke libaktheria tsa natto. E ka monngoa ke mala. The in vitro le in vivo thrombolytic properties tsa NK li khethiloe ka liteko, 'me ho fumanoe hore ts'ebetso ea in vivo thrombolytic ea NK e menahane ho feta ea enzyme ea fibrinolytic. E sebetsa ka potlako 'me e tšoarella nako e telele ka vivo, hape e ka etsa hore tPA e sebetse' meleng, e etsa hore e be bonolo Tsoela pele ho ntlafatsa ts'ebetso ea fibrinolytic ea mali. Bakuli ba kotsing ea ho hlaseloa ke myocardial infarction ba hloka ho kenya li-unit tse 300000 tsa urokinase ka nako, 'me ligrama tse 50 tsa natto li na le likarolo tse 800000 tsa urokinase bakeng sa thrombolysis.
Mesebetsi e ka sehloohong
phello e kholo ea nattokinase e sebetsa ka ho khetheha khahlanong le li-clots tsa khale tsa mali. Nattokinase e fihlella phello e tobileng ea thrombolytic ka ho hydrolyzing fibrin e kholo ea thrombus, 'me hajoale ke eona feela ntho ea tlhaho e fumanoang ho qhibilihisa thrombus ea khale.
Ka 2015, Univesithi ea Bongaka ea Tokyo e ile ea etsa liteko tsa thrombolytic ka nattokinase ho batho, ho tiisa hore nattokinase e ka ntlafatsa bokhoni ba 'mele oa fibrinolytic le ho qhala maqeba a mali ka katleho. Tlaleho ea lipatlisiso e na le sehlooho se reng "Single dose oral nattokinase thrombolysis and anticoagulation enhancement" 'me e hatisitsoe ho Scientific Reports 2015; 5: 11601.
Ka 2016, tekong ea 48 hora ea thrombolysis, 300FU ea nattokinase e ne e sebelisoa ho thrombi ea khale ho feta lihora tsa 56, e bontšang hore thrombus e ile ea qhibiliha ka ho feletseng ka hare ho lihora tsa 2; Lebelo la thrombolysis la ho sebelisa 150FU nattokinase le phahame haholo ho feta la ho sebelisa e lekanang le urokinase [1]. Liphuputso li bontšitse hore nattokinase ha e na phello ho plasma fibrinogen, e etsang hore e se ke ea tsoa mali. E ka boela ea kenya tšebetsong mokhoa oa 'mele oa thrombolytic, oa etsa hore' mele o itšireletse ho thrombosis ka ts'ebeliso ea nako e telele, ka tsela eo e netefatsa bophelo bo botle ba pelo le methapo ea pelo.
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Nako ea poso: Sep-11-2023
