Adenosine ke eng?

Adenosine ke nucleoside e hlahang ka tlhaho liseleng tsohle tsa 'mele. Ka lik'hemik'hale ke 6-amino-9-beta-D-ribofuranosyl-9-H-purine.

Sebopeho le maemo a mali

Adenosine e entsoe ka adenine e kopantsoeng le molek'hule oa tsoekere ea ribose (ribofuranose). Tlamo e kopanyang adenine le tsoekere ea ribose e bitsoa β-N9-glycosidic bond.

Boemo bo tloaelehileng ba plasma adenosine bo pakeng tsa 0.04 le 0.2 micromoles.

Karolo ea fisioloji le ea pharmacological ea Adenosine

'Meleng, adenosine e thusa ho fetisa matla a cellular ka ho etsa limolek'hule tse kang adenosine triphosphate (ATP) le adenosine diphosphate (ADP).

Adenosine e boetse e bapala karolo ea ho bontša litsela le mesebetsi e fapaneng 'meleng ka ho etsa limolek'hule tse kang cyclic adenosine monophosphate (cAMP).

Adenosine bokong

Bokong ba adenosine ke neurotransmitter e thibelang motho. Sena se bolela hore adenosine e ka sebetsa e le setsi sa khatello ea maikutlo. Maemong a tloaelehileng, e khothalletsa boroko le ho hatella ho tsosoa. Ha motho a tsohile, maemo a adenosine bokong a phahama hora e 'ngoe le e 'ngoe.

Adenosine ka pelong

Ka pelong adenosine e baka ho atoloha ha methapo ea mali e ntlafatsang phallo ea mali ho ea pelong. Adenosine e boetse e eketsa bophara ba methapo ea mali lithong tsa peripheral.

Pelong adenosine e fokotsa lebelo la pelo mme maling e na le ts'ebetso e khahlanong le liplatelete. Ketso ea antiplatelet e thibela ho kopana ha platelet le ho kopanya.

Adenosine maling

Ka mali adenosine e rojoa ke adenosine deaminase. Enzyme ena e teng liseleng tse khubelu le leboteng la sekepe. Setlhare Dipyridamole ke inhibitor ea enzyme adenosine deaminase 'me kahoo e phahamisa maemo a adenosine maling. Sena se lebisa ho atolosoeng ha methapo ea mali le ho ntlafatsa phallo ea mali ka methapo ea mali e fanang ka mesifa ea pelo.

Adenosine liphio, matšoafo le sebete

Liphiong adenosine e fokotsa phallo ea mali ea renal le ho fokotsa tlhahiso ea rennin ho tsoa liphio.

Matšoafong e baka tšitiso ea litsela tsa moea 'me sebeteng e lebisa ho thibaneng ha methapo ea mali le ho eketsa ho senyeha ha glycogen ho etsa tsoekere.

Adenosine ke motsoako o hlahang ka tlhaho o bapalang karolo ea bohlokoa lits'ebetsong tse fapaneng tsa 'mele oa motho. Ke nucleoside, e bolelang hore e entsoe ka molek'hule ea adenine e hokahaneng le molek'hule ea ribose. Adenosine e teng liseleng tsohle 'me e ameha phetisong ea matla e le karolo ea adenosine triphosphate (ATP), chelete ea mantlha ea matla ea sele. Ntle le karolo ea eona ho metabolism ea matla, adenosine e boetse e sebetsa joalo ka molek'hule e bonts'ang, e sebetsang ka li-receptor tse itseng 'meleng.

E 'ngoe ea likarolo tsa bohlokoa tsa pharmacology ea adenosine ke mokhoa oa eona oa ts'ebetso. Adenosine e sebetsa ka ho tlama li-receptor tse itseng tsa adenosine, tseo ho tsona ho nang le lihlopha tse 'nè: A1, A2A, A2B, le A3. Isoform e 'ngoe le e' ngoe e amahanngoa le mesebetsi e fapaneng ea 'mele le litsela tsa lipontšo. Ha adenosine e tlamella li-receptor tsa eona, e laola mekhoa e fapaneng ea lisele, ho kenyelletsa le neurotransmission, molumo oa methapo le ts'ebetso ea 'mele ea ho itšireletsa mafung. Ka mohlala, ts'ebetso ea li-receptor tsa A1 e ka lebisa ho thibela ho lokolloa ha li-neurotransmitter, ha ts'ebetso ea li-receptor tsa A2A e ka lebisa ho vasodilation le liphello tse khahlanong le ho ruruha.

Ho utloisisa pharmacology ea adenosine ho lebisa lits'ebetsong tsa bongaka maemong a fapaneng a bongaka. E 'ngoe ea litšebeliso tse tsebahalang haholo tsa bongaka tsa adenosine ke karolo ea eona kalafong ea li-arrhythmias tse itseng tsa pelo. Adenosine e sebelisoa e le moemeli oa antiarrhythmic ka lebaka la bokhoni ba eona ba ho liehisa tsamaiso ka node ea atrioventricular, kahoo e sitisa tsela e khutlelang morao le ho khutlisetsa morethetho o tloaelehileng oa sinus. Ho phaella moo, adenosine e sebelisoa e le moemeli oa khatello ea meriana lithutong tsa ho nahana ka pelo ho lekola phallo ea myocardial.

Ka bokhutšoanyane, adenosine ke molek'hule e nang le mefuta e mengata e nang le lisebelisoa tse ngata tsa kliniki ka lebaka la thepa ea eona ea meriana le mokhoa oa ho sebetsa. Bokhoni ba eona ba ho fetola mekhoa ea lisele ka ho sebelisana ka mokhoa o khethehileng oa li-receptor ho etsa hore e be sesebelisoa sa bohlokoa sa ho phekola maemo a sa tšoaneng a bongaka, ho tloha ho arrhythmias ea pelo ho ea ho mafu a ho hema hammoho le lisebelisoa tse ka 'nang tsa e-ba le neuroprotective. Ha lipatlisiso ka adenosine li ntse li tsoela pele, tšebeliso e ncha ea tleliniki bakeng sa molek'hule ena e khahlang e ka 'na ea tsoela pele ho hlaha, e ntse e atolosa matla a eona a phekolo meriana.

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